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YourClinicalPharmacist

Learning together through evidence-based research

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I'm a mom of 3 and a clinical pharmacist passionate and determined to help my autisitc son and all autistic kids and their families. I'm a complete nerd and love research, learning from scientific studies, educating, and advocating. 'm sharing my findings as I review scientific studies regarding autism, ADHD, anxiety, inflammatory and autoimmune conditions, oncology, vaccines, various toxins, and overall health - so why not learn too? Hopefully we'll promote and drive change in the process. Follow me for an educational journey.

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Metal Neurotoxicity

Neurobehavioral toxic effects of perinatal oral exposure to aluminum on the developmental motor reflexes, learning, memory and brain neurotransmitters of mice offspring
Association between serum folate concentrations and blood lead levels in adolescents: A cross-sectional study
Neurotoxic effects of combined exposures to aluminum and mercury in early life (infancy)
Core Concepts: Development of the Blood-Brain Barrier
The role of the placenta in fetal exposure to heavy metals
Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders

Aluminum in Vaccines

Aluminium in the Human Brain: Routes of Penetration, Toxicity, and Resulting Complications
Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication
Alulminium in brain tissue in autism
Aluminium in human brain tissue from donors without neurodegenerative disease: A comparison with Alzheimer’s disease, multiple sclerosis and autism
Aluminium in plasma and tissues after intramuscular injection of adjuvanted human vaccines in rats
Aluminum access to the brain: a role for transferrin and its receptor
Aluminum Toxicity
Aluminum Neurotoxicity in Preterm Infants Receiving Intravenous-Feeding Solutions
Aluminum-induced oxidative stress promotes changes in the structure of the gut microbiota and liver deficiency
Aluminum causes irreversible damage to the development of hippocampal neurons by regulating m6A RNA methylation
ToxGuide for Aluminum
Aluminum causes irreversible damage to the development of hippocampal neurons by regulating m6A RNA methylation
Infant Vaccine Aluminum Content Chart
610.15 Constituent materials.
Do aluminum vaccine adjuvants contribute to the rising prevalence of autism?
Epub 2017 Dec 28. Critical analysis of reference studies on the toxicokinetics of aluminum-based adjuvants
Disparate adjuvant properties among three formulations of “alum”
Highly delayed systemic translocation of aluminum-based adjuvant in CD1 mice following intramuscular injections

Package Inserts

Abrysvo PI
Infanrix PI
Quadracel PI
Pediarix PI
Beyfortus PI
Recombivax PI
Rotarix PI
ActHib PI
Boostrix PI
Rotateq PI
Vaxelis PI
Kinrix PI
PedVaxHib PI
Pentacel PI
IPOL PI
Daptacel PI

Autism and Inflammation

The role of the placenta in fetal exposure to heavy metals
Mast Cells and Neuroinflammation
Aluminum causes irreversible damage to the development of hippocampal neurons by regulating m6A RNA methylation
Chelation: Harnessing and Enhancing Heavy Metal Detoxification—A Review
Chelation: Harnessing and Enhancing Heavy Metal Detoxification—A Review
Epigenetic Mechanisms of Aluminum-Induced Neurotoxicity and Alzheimer's Disease: A Focus on Non-Coding RNAs
Epigenetic Mechanisms of Aluminum-Induced Neurotoxicity and Alzheimer's Disease: A Focus on Non-Coding RNAs
Epigenetic Mechanisms of Aluminum-Induced Neurotoxicity and Alzheimer's Disease: A Focus on Non-Coding RNAs
Epigenetic Mechanisms of Aluminum-Induced Neurotoxicity and Alzheimer's Disease: A Focus on Non-Coding RNAs
Epigenetic Mechanisms of Aluminum-Induced Neurotoxicity and Alzheimer's Disease: A Focus on Non-Coding RNAs
TESTING
Focal brain inflammation and autism
Anti-Inflammatory and Neuroprotective Polyphenols Derived from the European Olive Tree, Olea europaea L., in Long COVID and Other Conditions Involving Cognitive Impairment

Inulin

Dietary Inulin Supplementation Modulates Short-Chain Fatty Acid Levels and Cecum Microbiota Composition and Function in Chickens Infected With Salmonella

Luteolin

Luteolin (LUT) Induces Apoptosis and Regulates Mitochondrial Membrane Potential to Inhibit Cell Growth in Human Cervical Epidermoid Carcinoma Cells (Ca Ski)
Luteolin as an anti-inflammatory and neuroprotective agent: A brief review
Luteolin
Luteolin mitigates oxidative stress and multi-organ impairment in a propionic acid-induced rodent model of autism
NeuroProtek Low Phenol Algonot
Endocrine Disrupting Activities of the Flavonoid Nutraceuticals Luteolin and Quercetin
The role of glutathione redox imbalance in autism spectrum disorder: A review
Effectiveness of N-acetylcysteine in autism spectrum disorders: A meta-analysis of randomized controlled trials

Folate/MTHFR

One Carbon Metabolism and Epigenetics: Understanding the Specificity
Serum binding folate receptor autoantibodies lower in autistic boys and positively-correlated with folate
Folic Acid and Autism: A Systematic Review of the Current State of Knowledge
Folate receptor autoimmunity and cerebral folate deficiency in low-functioning autism with neurological deficits
Autoantibodies to Folate Receptors in the Cerebral Folate Deficiency Syndrome
Biological Role of Folic Acid in Pregnancy and Possible Therapeutic Application for the Prevention of Preeclampsia
Active Folate Versus Folic Acid: The Role of 5-MTHF (Methylfolate) in Human Health
Effect of folic acid supplementation on aluminum accumulation in rats
Methylenetetrahydrofolate reductase and psychiatric diseases
MTHFR Gene Variant and Folic Acid Facts
Molecular Biology of Methylenetetrahydrofolate Reductase (MTHFR) and Overview of Mutations/Polymorphisms
Common folate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment☆
Active Folate Versus Folic Acid: The Role of 5-MTHF (Methylfolate) in Human Health
One-Carbon Metabolism Nutrients, Genetic Variation, and Diabetes Mellitus
Methylenetetrahydrofolate Reductase Deficiency
One-Carbon Metabolism in Health and Disease
Detection of 677CT/1298AC “double variant” chromosomes: Implications for interpretation of MTHFR genotyping results
Interrelation between homocysteine metabolism and the development of autism spectrum disorder in children

Neurotransmitters

Physiology, Neurotransmitters
Neurotransmitter Receptor
Neurotransmitter
Exploring the serotonin-probiotics-gut health axis: A review of current evidence and potential mechanisms
Gut Bacteria and Neurotransmitters
Biochemistry, Gamma Aminobutyric Acid
Corticotropin-releasing hormone and brain mast cells regulate blood-brain-barrier permeability induced by acute stress
The Multifaceted Therapeutic Role of N-Acetylcysteine (NAC) in Disorders Characterized by Oxidative Stress
Effects of microbiome changes on endocrine ghrelin signaling – A systematic review
Microbiota fasting-related changes ameliorate cognitive decline in obesity and boost ex vivo microglial function through the gut-brain axis
Effect of Time-Restricted Eating on Weight Loss in Adults With Type 2 Diabetes

Zeolite

ZeOxaNMulti Trial: A Randomized, Double-Blinded, Placebo-Controlled Trial of Oral PMA-zeolite to prevent Chemotherapy-Induced Side Effects, in particular, Peripheral Neuropathy
Zeolite Clinoptilolite: Therapeutic Virtues of an Ancient Mineral
The Use of Biochar as a Soil Amendment to Reduce Potentially Toxic Metals (PTMs) Phytoavailability
Adsorption of heavy metals on natural zeolites: A review
The Dr. Paul Approved Vaccine Plan
Vaccines and sudden infant death: An analysis of the VAERS database 1990-2019 and review of the medical literature

Infant Development

The Immature Infant Liver: Cytochrome P450 Enzymes and their Relevance to Vaccine Safety and SIDS Research
Developmental patterns in human blood-brain barrier and blood-cerebrospinal fluid barrier ABC drug transporter expression
CDC National Center for Health Statistics - Key Birth Statistics
Barrier Mechanisms in the Developing Brain
Physiology and molecular biology of barrier mechanisms in the fetal and neonatal brain
Uncoupling of the Infancy Life History Stage
The most immature infants: Is evidence-based practice possible?
Evo-Devo of Infantile and Childhood Growth
Infant functional status: the timing of physiologic maturation of premature infants
Immune system: development and acquisition of immunological competence
KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease
The Impact of Sleep Dysregulation on Autism
Daily magnesium fluxes regulate cellular timekeeping and energy balance
Aluminum decreases the magnesium concentration of spinal cord and trabecular bone in rats fed a low calcium, high aluminum diet
Dietary Protocols to Promote and Improve Restful Sleep: A Narrative Review
Low dietary intake of magnesium is associated with increased externalising behaviours in adolescents
Magnesium acts as a second messenger in the regulation of NMDA receptor mediated CREB signaling in neurons
Mg2+ block properties of triheteromeric GluN1–GluN2B–GluN2D NMDA receptors on neonatal rat substantia nigra pars compacta dopaminergic neurones
Magnesium in neuroses and neuroticism
Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial
Lipopolysaccharide From E. coli Increases Glutamate-Induced Disturbances of Calcium Homeostasis, the Functional State of Mitochondria, and the Death of Cultured Cortical Neurons
Simultaneous effects of aluminum exposure on the homeostasis of essential metal content in rat brain and perturbation of gut microbiota
Aluminum-induced oxidative stress promotes changes in the structure of the gut microbiota and liver deficiency
Aluminum-induced generation of lipopolysaccharide (LPS) from the human gastrointestinal (GI)-tract microbiome-resident Bacteroides fragilis
Effects of subchronic oral toxic metal exposure on the intestinal microbiota of mice
A Summary of the Biological Processes, Disease-Associated Changes, and Clinical Applications of DNA Methylation
Aluminum promotes B1 cells to produce IL-10 and impairs adaptive immune system
Association between serum folate concentrations and blood lead levels in adolescents: A cross-sectional study
Environmentally relevant metal and transition metal ions enhance Fc epsilon RI-mediated mast cell activation
Advances on the early cellular events occurring upon exposure of human macrophages to aluminum oxyhydroxide adjuvant
Aluminum induces inflammatory and proteolytic alterations in human monocytic cell line
Novel cellular and molecular mechanisms of induction of immune responses by aluminum adjuvants
Chronic Oral Administration of Aluminum Hydroxide Stimulates Systemic Inflammation and Redox Imbalance in BALB/c Mice
Toxicological consequences of experimental exposure to aluminum in human intestinal epithelial cells
Resveratrol alleviates aluminum-induced intestinal barrier dysfunction in mice
Based on 16 S rRNA sequencing and metabonomics to reveal the new mechanism of aluminum potassium sulfate induced inflammation and abnormal lipid metabolism in mice
Aluminum-induced generation of lipopolysaccharide (LPS) from the human gastrointestinal (GI)-tract microbiome-resident Bacteroides fragilis
Simultaneous effects of aluminum exposure on the homeostasis of essential metal content in rat brain and perturbation of gut microbiota
Simultaneous effects of aluminum exposure on the homeostasis of essential metal content in rat brain and perturbation of gut microbiota
Aluminum induced intestinal dysfunction via mechanical, immune, chemical and biological barriers
Effects of Aluminum on the Integrity of the Intestinal Epithelium: An in Vitro and in Vivo Study
Aluminum Enters Mammalian Cells and Destabilizes Chromosome Structure and Number
Effects of occupational exposure to aluminium on some oxidative stress and DNA damage parameters
Genotoxic effects of aluminum chloride in cultured human lymphocytes treated in different phases of cell cycle
Aluminium-induced oxidative DNA damage recognition and cell-cycle disruption in different regions of rat brain
Aluminum (Al) causes a delayed suppression of nucleotide excision repair (NER) capacity in zebrafish (Danio rerio) embryos via disturbance of DNA lesion detection
Epigenetic Mechanisms of Aluminum-Induced Neurotoxicity and Alzheimer's Disease: A Focus on Non-Coding RNAs
Epigenetic Mechanisms of Aluminum-Induced Neurotoxicity and Alzheimer's Disease: A Focus on Non-Coding RNAs
Aluminum promotes B1 cells to produce IL-10 and impairs adaptive immune system
Effects of aluminum on immune functions of cultured splenic T and B lymphocytes in rats
Aluminium adjuvants in vaccines - A way to modulate the immune response
Aluminum causes irreversible damage to the development of hippocampal neurons by regulating m6A RNA methylation
METTL3-mediated m6A RNA methylation was involved in aluminum-induced neurotoxicity
Epigenetic Mechanisms of Aluminum-Induced Neurotoxicity and Alzheimer's Disease: A Focus on Non-Coding RNAs
Whole-transcriptome analysis of aluminum-exposed rat hippocampus and identification of ceRNA networks to investigate neurotoxicity of Al
Nanomolar aluminum induces pro-inflammatory and pro-apoptotic gene expression in human brain cells in primary culture
Run-on gene transcription in human neocortical nuclei. Inhibition by nanomolar aluminum and implications for neurodegenerative disease
Entry and Deposit of Aluminum in the Brain
The toxicology of aluminum in the brain: a review
Aluminium in the Human Brain: Routes of Penetration, Toxicity, and Resulting Complications
Chronic aluminum intake causes Alzheimer's disease: applying Sir Austin Bradford Hill's causality criteria
Biopersistence and brain translocation of aluminum adjuvants of vaccines
Based on 16 S rRNA sequencing and metabonomics to reveal the new mechanism of aluminum potassium sulfate induced inflammation and abnormal lipid metabolism in mice
Aluminum enhances inflammation and decreases mucosal healing in experimental colitis in mice
Toxicological consequences of experimental exposure to aluminum in human intestinal epithelial cells
Aluminum-induced generation of lipopolysaccharide (LPS) from the human gastrointestinal (GI)-tract microbiome-resident Bacteroides fragilis
Aluminum enhances inflammation and decreases mucosal healing in experimental colitis in mice
Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles
Polysorbate-80 coating enhances uptake of polybutylcyanoacrylate (PBCA)-nanoparticles by human and bovine primary brain capillary endothelial cells
Nanotoxicity of poly(n-butylcyano-acrylate) nanoparticles at the blood-brain barrier, in human whole blood and in vivo
Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier
Surfactants, not size or zeta-potential influence blood-brain barrier passage of polymeric nanoparticles
Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication
Entry and Deposit of Aluminum in the Brain
Aluminium in the Human Brain: Routs of Penetration, Toxicity, and Resulting Complications
N-Acetyl Cysteine (NAC): Nootropic Benefits, Dosage & Side Effects
N-acetylcysteine prevents stress-induced anxiety behavior in zebrafish
N-Acetylcysteine (NAC): Impacts on Human Health
https://pmc.ncbi.nlm.nih.gov/articles/PMC4842352/
N-Acetylcysteine May Regulate Altered Meteorin-Like Levels in Testicular Tissue due to Aluminum Exposure

NAC

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